Is weak blood flow the thing behind dementia?

"This cover image depicts a human brain with colorful microplastic particles scattered across its surface, juxtaposed with a white plastic spoon as a visual representation. Research has revealed that the human brain contains approximately “a spoon’s worth” of microplastics and nanoplastics, with particularly high concentrations (3-5 times greater) in individuals with dementia. The multicolored particles shown on the brain surface represent the variety of plastic types detected, with polyethylene being predominant. The image illustrates the concerning 50% increase in microplastic concentration observed between 2016 and 2024, highlighting the rapid infiltration of these synthetic materials into our most protected organ. Credit: Genomic Press" (ScitechDaily, Scientists Discover Alarming Amount of Microplastics in Your Brain – And It Could Be Fueling Depression and Dementia)

"A groundbreaking set of four papers in the May issue of Brain Medicine brings together growing evidence that microplastics from ultra-processed foods may be building up in human brains and possibly playing a role in the global rise of depression, dementia, and other mental health disorders." (ScitechDaily, Scientists Discover Alarming Amount of Microplastics in Your Brain – And It Could Be Fueling Depression and Dementia)

There are lots of microplastics in dementia patients' brains. There must be something that causes microplastic accumulation in human brains. And there is a possibility. That is the same thing that causes dangerous protein accumulation in human brains. If microplastics go into the cell, that thing can cause a situation where those particles start to resonate. That resonance can cause pressure waves in cells. 

There is also the possibility that microplastics, along with some proteins, can go through axonal holes. If there are some other particles. And proteins that accumulate between axons. That denies the neurotransmitter’s ability to travel between axons and neurons. 

There is a possibility that the microplastic accumulation in dementia patients' brains is caused by: 

1) Anatomic disorders in the human brain’s blood vessels. Or something else that can cause slow blood flow in those blood vessels. If things like nutrients have no access to brains and neurons, that makes those cells weaker than usual. 

There is a possibility that the coronary artery disease-type things can cause dementia. But is that something in the blood vessels or the lymphatic system? 

2) There is also a possibility that the disorder can be in the lymphatic system. That means the lymphatic system cannot, for some reason, transport those microplastics and proteins out from the brain. 

And the primary question is, are those microplastics the reason for dementia? Or are they symptoms of the thing that causes Alzheimer's? Are the blood vessels of the dementia patient’s brain just rougher than a person's blood vessels that have no dementia? The slight inner shell of blood vessels will not collect proteins, lipids, and microplastics in blood vessels. There is a possibility that the blood flow is slower in those patients' brains. 

And that collects dirt into the veins. If the blood flow in human brains is very slow, there is a possibility that this thing collects dirt, like proteins, into those blood vessels. One possibility is that the reason for dementia is that the brain's blood vessels are so stiff that they cannot remove those particles from the brain.

 And that can cause an induction conclusion. Are the blood vessels in dementia patients’ brains similarly crammed as the coronary arteries have narrowed in coronary artery disease? There is a possibility that those crammed veins are in the lymphatic system. If the lymphatic system does not carry garbage away, it can collect proteins and microplastics in blood vessels. 

So is there some kind of dysfunction or anomaly in the dementia patient’s brain or brain's blood vessels? The thing that can collect microplastics in the brain can be the weak or slow blood flow. That thing can collect those microplastics in certain people's brains. And that can be the thing that makes those microplastics a symptom of dementia. 

When we think about the weak blood movement. As the thing that can cause dementia, that thing can cause a situation where bad proteins are accumulating in the brain, the same way as microplastics accumulate in the brain. If that thing is possible to prove, that is the fundamental thing in dementia research. 

https://www.eurekalert.org/news-releases/1074296?

https://www.emjreviews.com/neurology/news/microplastics-found-in-human-brains-an-alarming-link-to-dementia/

https://scitechdaily.com/scientists-discover-alarming-amount-of-microplastics-in-your-brain-and-it-could-be-fueling-depression-and-dementia

How dangerous can microplastics be?

"Plastics affect every aspect of the Earth system, from climate change to biodiversity, due to the thousands of chemicals in their life cycle, impacting environmental and human health. A new study calls for understanding plastics pollution beyond waste management, using a planetary boundaries framework to highlight plastics’ global, interconnected impacts." (ScitechDaily, Not As Harmless as Scientists Thought: Plastics Are Threatening Earth’s Stability)

Microplastics are small pieces of plastics that are filling oceans. Those things form in things like the cosmetic industry. The reason why those things are used is that they should not be poisonous. The plastic itself is not poisonous. But when we think about the microplastics. Those things act like nanomachines. When things like krill eat some algae those microplastics get in their body. 

The microplastics are very dangerous to bacteria. If bacteria eat those small plastic bites that can cause internal damage to its structure. Sometimes some researchers introduced that some cancer medicines will replaced by microplastic nanomachines. The problem was how to remove those things from the body. 

If those microplastics are covered using nutrients that certain bacteria or cancer cells eat, those small plastic bites can slip into those cells and destroy their internal structure. The nano- and microplastics can slip into the cells and even fill them. 

There those small plastic bites travel in the food chain. And finally, they return to the human saucer and our food. The thing that makes microplastics dangerous is that it's possible that they get into cells. In those cases, the cells can damaged or even die if those microplastics harm their internal structures. 

There are many points where the microplastic can touch and cause damage. Those microplastics can clog the pipelines in cell organs. That causes errors in the cell's normal functions.  The microplastic can damage the cell's mitochondria or even destroy them. Or it can cause damage to the cell's nucleus. 

Or they can jam the cell's ion pumps. The string- or stick-shaped microplastic can make holes in the cell's protein shell or it can stuck into the ion pump. That keeps the ion pump open all the time. Microplastics can damage even big animal embryos if they get into a morula. But microplastics can endanger things like plankton. And through plankton, those small plastic bites can go into the human body. 

https://scitechdaily.com/not-as-harmless-as-scientists-thought-plastics-are-threatening-earths-stability/